Relationship Between Glutathione S-Transferase M1,T1 Genetic Polymorphisms, Smoking and Alcohol Consumption and Susceptibility to Stomach Cancer
- VernacularTitle:谷胱甘肽转硫酶M1、T1基因型及烟酒嗜好与胃癌易感性的关系
- Author:
Jiao ZHANG
;
Xiaobing SHEN
;
Liangjun ZHU
- Publication Type:Journal Article
- Keywords:
Disease susceptibility;
Stomach neoplasms;
Glutathione S-transferase;
Genetic polymorphisms
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the association of glutathione-stransferase M1(GSTM1), T1(GSTT1) genetic polymorphisms, smoking and alcohol consumption with the risk of gastric cancer. Methods 1:1 matched case-control study and molecular epidemiology technique were used to analysis the genetic polymorphisms of GSTM1, GSTT1 genotype among 60 cases of gastric cancer patients and sex-and age-matched controls, who were selected from Nanjing Zhongda Hospital and Jiangsu Province Cancer Hospital. Statistical analysis was performed to elucidate interaction of GSTM1. GSTT1 genotype and smoking and alchol consumption in the risk for stomach cancer. Results The frequency of GSTT1 null genotype among cases and controls was 61.67% and 40.00% respectively (?2 =6.08, P
