Protective effect of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation
- VernacularTitle:非糖皮质激素的免疫抑制方案对同种异体移植胰岛的保护作用
- Author:
Erkan XU
;
Chengyou DU
- Publication Type:Journal Article
- Keywords:
Immunosuppressive agent;
Islets of langerhans transplantation;
Glucocorticoid;
Rat
- From:
Chinese Journal of Organ Transplantation
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of anti-rejection of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation.Methods Tacrolimus (FK506)+ mycophenolate mofetil (MMF) and FK506+MMF+prednisone (Pred) were administered respectively for two weeks to inhibit rejection after allogenic islet transplantation in rats,which were compared with control group. The concentrations of blood glucose,insulin and C-peptide were determined dynamically in recipients and the sites of transplantation were observed morphologically.Results As compared with control group without immunosuppressive agents,FK506+MMF and FK506+MMF+Pred could prolong the survival time of grafts significantly. There were many morphologically intact islets in liver of recipients two months after transplantation. Group FK506+MMF kept normal blood glucose,insulin and C-peptide beyond 60 days after transplantation,but compared with the former,group FK506+MMF+Pred secreted less C-peptide ( P
