Role of mycoplasma pneumoniae infection in exacerbated stage of COPD and on celluler immune system of community acquired pneumonia patients
- VernacularTitle:肺炎支原体感染对老年慢性阻塞性肺疾病急性发作及肺炎患者免疫功能的影响
- Author:
Chaosheng DENG
;
Meiyun CHEN
;
Qichang LIN
;
Kegui WU
;
Aizhong TANG
;
Yirui WENG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,obstructive;
Mycoplasma pneumoniae;
Cytokines
- From:
Chinese Journal of Geriatrics
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of pulmonary mycoplasma pneumoniae(MP) infection with acute exacerbated stages of chronic obstructive pulmonary disease(COPD) and community acquired pneumonia(CAP)in the elderly,comparing different serum concentrations of IFN -? ,IL-6,TNF-? in these patients. Methods Serologic analysis through ELISA method was used to detect MP-IgM and MP-IgG to determine the presence of MP and the serum concentrations of IFN-?、IL-6、TNF-? in 30 elderly healthy subjects,39 elderly patients with acute exacerbated stage of COPD and 40 elderly patients with CAP. PCR method was also used to determine the presence of MP from the patients ,sputum. Results (1)The positive rates of MP were much higher in the COPD patients than in the CAP and healthy ones according to PCR or MP-IgM method( P
