The significance of AgNORs of peripheral T lymphocytes in the diagnosis of elderly cancer
- VernacularTitle:T细胞核仁组成区嗜银蛋白对老年人肿瘤诊断的价值
- Author:
Xinan SHENG
;
Lin YI
;
Jianyu WU
;
Meizhen ZHOU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
T-Lymphocytes;
Chromatin
- From:
Chinese Journal of Geriatrics
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic significance of argyrophilic nuclear organizer regions(AgNORs) of peripheral T lymphocytes in elderly cancer patients. Methods AgNORs was examined using KL tumor image analysis system in 45 cases of health control,36 cases of elderly inflammatory patients,97 cases of elderly cancer patients and 30 cases of elderly tumor-cured patients. CD3,CD4,CD8,CD4/8 and NK were detected by flow cytometer in cancer patients. Results Compared with normal controls,inflammation and tumor-cured patients,AgNORs was decreased extremely in elderly patients with cancer. Moreover,AgNORs was decreased in tumor metastasis status. Conclusions In analyzed elderly cancer patient cases,the expression of AgNORs is significantly decreased. The AgNORs may serve as a marker for judgment of clinical treatment and supervisor.
