Effect of madopar on nerve cell apoptosis of rats with Parkinson's disease
- VernacularTitle:美多芭对帕金森病大鼠细胞凋亡的影响
- Author:
Jiancheng HE
;
Canxing YUAN
;
Hongchang WEI
;
Ruxing CHEN
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Dopamine agents;
Apoptosis
- From:
Chinese Journal of Geriatrics
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To illustrate the effect of Madopar on nerve cell apoptosis of rats with Parkinson’s disease (PD). Methods Hemi-lateral PD model was made by injecting 6-OHDA into the black substance of the right side of the brain and treated with Madopar. At the same time,the normal group and sham-operation group were set up,and TUNEL staining and transmission electro-speculum were employed to observe the apoptosis of nerve cells. Results The TUNEL positive cells(23.50?3.85) were significantly less than the model group(37.83?6.46) and the comparison of apoptosis cells counting showed marked difference( P
