Study on the expression of cyclooxygenase-2 protein in gastric carcinoma and correlation with P-glycoprotein
- VernacularTitle:胃癌组织中环氧合酶-2表达及其与P-gp表达相关性的研究
- Author:
Jun LIU
;
Haihang ZHU
;
Ping BO
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
cyclooxygenase-2;
multidrug-resistant;
P-glycoprotein
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the cyclooxygenase-2(COX-2) expression in gastric carcinoma and investigate the effects of COX-2 expression on P-glycoprotein. Methods:The expression of COX-2 and P-glycoprotein was examined by immunohistochemical staining in 48 cases of gastric carcinoma and 10 cases of normal gastric tissues. Results:There was no positive signal of COX-2 detected in normal gastric tissue. The positive expression rate of COX-2 was 60.4 %(29/48) in gastric carcinoma. The expression of COX-2 was correlated with TNM stage and lymph node metastasis (P
