A study on expression of KGF mRNA in human NSCLC and its role in the development of lung cancer
- VernacularTitle:KGF在人NSCLC中的表达及意义
- Author:
Ling LIU
;
Jiping DA
;
Chunron SUN
- Publication Type:Journal Article
- Keywords:
keratinocyte growth factor (KGF);
non-small cell lung cancer(NSCLC);
in situ hybridization (ISH)
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate expression of keratinocyte growth factor(KGF) messenger ribonuclunc acid in human NSCLC and to study the role of KGF in the development of NSCLC. Methods:The expression of KGF mRNA in 50 cases with NSCLC was detected by in situ hybridization (ISH). Results:On ISH slides, positive KGF mRNA was mainly shown as fusiform stain in plasma of fibroblast and blood vessel smooth muscle cell in mesenchymal of NSCLC, also, some parenchyma cell plasma was stained. The positive rate of KGF mRNA in tumor(86%) is statistically higher than that in normal tissue(24%)(P
