Expression and clinical significance of PTEN in non-small cell lung cancer
- VernacularTitle:PTEN蛋白阳性在非小细胞肺癌的临床意义
- Author:
Wenjian LIU
;
Zhehai WANG
;
Meiqing HE
- Publication Type:Journal Article
- Keywords:
PTEN protein;
non-small cell lung cancer;
immunohistochemistry;
prognosis
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression and clinical significance of PTEN in non-small cell lung cancer. Methods:Immunohistochemical staining was used to determine the expression of PTEN in 10 cases of normal lung issues and 56 cases of non-small cell lung cancer. Results:The positive incidences of PTEN expression in NSCLC was 59% while positive expression was found in all normal lung issues. The expression of PTEN was correlated to degree of differention of cancer, lymph node metastasis and clinical stages. The PTEN negative group was seen to have the worst survival rate among all groups. Conclusions:The results suggest that PTEN gene plays an important role in carcinogenesis and progress of NSCLC. Expression of PTEN may be valuable in prognosis assessment of NSCLC.
