Study on the expression of neuron-specific enolase,chromogranin and synaptophysin in functional islet cell tumors
- VernacularTitle:神经内分泌标记物NSE、CG和SYN在功能性胰岛细胞瘤中的表达研究
- Author:
Kuirong JIANG
;
Xunliang LIU
;
Yi MIAO
;
Zhaoxun ZHEN
;
Zhekuan XU
;
Zhuyin QIAN
;
Cuncai DAI
- Publication Type:Journal Article
- Keywords:
Islet cell tumor?Chromogranins?Synaptophysin?Neuron-specific enolase
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression and clinical significance of neuron-specific enolase,chromogranin and synaptophysin in islet cell tumors.Methods:Twenty-one paraffin-embedded specimens with islet tumors and 3 cases cholangiocarcinoma and tissue nearby the tumor were recruited from Jan 1988 to Jun 2001.The S-P method was used for the detection of chromogranin,synaptophysin and neuron-specific enolase.Results:There were positive expressions of neuron-specific enolase,chromogranin and synaptophysin in 19,15 and 18 cases respectively,while negative results were observed in 3 cases of cholangiocarcinoma and the para-cancer tissue.Conclusion:CG,SYN and NSE may be specific tumor markers of islet cell tumors and combined detection can help to enhance the sensitivity.
