The expression of NF-?Bp65 and bcl-x_ L gene in pancreatic carcinoma and their significance
- VernacularTitle:核因子-?Bp65及bcl-x_L基因在胰腺癌组织中表达及意义
- Author:
Zhaohui SHI
;
Xihong JIANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms?NF-kappa B?Genes,bcl-x L?Gene expression
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of NF-?Bp65 and bcl-x L gene in pancreatic carcinoma and their clinical significance.Methods:The expressions of NF-?Bp65 and bcl-x L protein in 52 pancreatic carcinoma were studied by immunohistochemistry,and their relationship to clinical pathology were analyzed.Results:The positive rates of NF-?Bp65 protein and bcl-x L protein in pancreatic carcinoma were 63.5% and 73.1% respectively,and which were higher than those of normal pancreatic tissues.The expression of NF-?Bp65 was related to tumor diameter,TNM stage and lymph node metastasis,and had no relation with the extent of differentiation and type of pathology.There was positive correlation between NF-? Bp65 and bcl-x L expression.Conclusion:NF-? Bp65 may be an important oncoprotein,and may have positive regulation on bcl-x L,then promote tumorgenesis.
