Mechanism of femoral head necrosis induced by long term glucocorticoid treatment in rabbit model
- VernacularTitle:激素对股骨头微血管及组织细胞的影响
- Author:
Changgen HU
;
Junchang CHEN
;
Qiang LIU
- Publication Type:Journal Article
- Keywords:
Femur head necrosis;
Glucocorticoids;
Animals, laboratory;
Microscopy, electron
- From:
Chinese Journal of Orthopaedics
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of the femoral head necrosis induced with long term glucocorticoid treatment by means of microvascular density and cellular ultrastructure. Methods 40 Japanese rabbits were used to establish an animal model of the femoral head necrosis induced by long term glucocorticoid treatment using injection with methylprednisolone 8 mg/kg weekly. In studying cellular ultrastructure and microvascular density of the femoral head necrosis models, the slides were made after vascular infusion with Chinese ink on 4th, 8th, and 12th week of the experiment. The network of microvasculature of the rabbit ear was photographied as a reference data before and after methylprednisolone treatment. Results Microvascular density in bilateral cancellous and compact bone of the femoral head became decreased statistically after 12 weeks of glucocorticoid treatment(P
