Long-term Prognosis of IgA Nephroapthy.
- Author:
Gyu Bok JIN
1
;
Jung Eun KIM
;
Jeong Soo YOON
;
Jung Hoon SUNG
;
Jin Ho KWAK
;
Eun Ah WHANG
;
Seung Yeup HAN
;
Sung Bae PARK
;
Hyun Chul KIM
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. K780121@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
IgA nephropathy;
Long-term prognosis
- MeSH:
Biopsy;
Glomerulonephritis;
Glomerulonephritis, IGA;
Humans;
Hypertension;
Immunoglobulin A*;
Kidney Failure, Chronic;
Prognosis*;
Proteinuria;
Renal Insufficiency;
Retrospective Studies;
Risk Factors;
Survival Rate
- From:Korean Journal of Nephrology
2006;25(3):365-373
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: IgA nephropathy (IgAN) is the most frequent primary glomerulonephritis in the world. Despite 20 years of research into this condition, much remains unknown about its pathogenesis and therapy. One major problem is that the prognostic evaluation and renal survival of IgAN is unreliable. METHODS: A retrospective study was performed to clarify the prognostic factors and the long-term renal survival rates of this disease. RESULTS: One hundred fifty-two patients with IgAN who followed-up at least 3 years after renal biopsy were included in this study. During a mean followed-up of 9.3 years after their renal biopsy (range:36-215 months), 33 of them (21.7%) had progressed to end-stage renal disease (ESRD). The actuarial renal survival rate was 97% at 5 years, and 85% at 10 years. Using univariate analysis, 5 risk factors for developing ESRD were identified:male sex, hypertension, heavy proteinuria, renal insufficiency at the time of biopsy, severe histopathologic findings such as subclass IV/V lesions by Haas' subclassification were associated with significant risk factors for developing ESRD. In multivariate regression analysis, only Haas' subclass IV/V lesions and renal insufficiency at the time of biopsy were the independent prognostic factors of IgAN. CONCLUSION: In conclusion, further long-term prospective study with larger number of patients would be necessary to assess the prognostic factors in IgAN.
