A morphologic study of the effect of rosiglitazone on aortic endothelia in insulin-resistant rats
- VernacularTitle:罗格列酮对胰岛素抵抗大鼠胸主动脉内皮细胞作用的形态学观察
- Author:
Ying LIU
;
Ying ZHAO
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
Rosiglitazone;
Insulin resistance;
Endothelium, vascular;
Aorta;
Ultrastructure
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of rosiglitazone on pathologic changes in the ultrastructure of aortic endothelia in insulin-resistant (IR) rats. Methods IR rat model was prepared in 6-8-week-old SD rats by high-glucose chaw (70% calories from glucose) for 6 weeks. IR rat model was divided into IR group (n=10) and rosiglitazone (RSG) group (n=10). Rats in RSG group were given rosiglitazone 10 ?mol?kg -1?d -1 (16:00) by gavage for 6 weeks. Ultrastructure of aortic endothelia was observed with transmission electron microscope. Results Systolic blood pressure and serum levels of triglyceride, free fatty acid and insulin in RSG group were lower than those in IR group (both P
