Morphologic observation of the effect of rosiglitazone on ? cells in insulin-resistant rats
- VernacularTitle:罗格列酮对胰岛素抵抗大鼠?细胞作用形态学观察
- Author:
Ying LIU
;
Ying ZHAO
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
Rosiglitazone;
Insulin resistance;
Islet ? cells;
Ultrastructure
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of rosiglitazone on pathologic changes of ? cell ultrastructure in insulin-resistant (IR) rats. Methods IR rat model was established in 6-8-week-old SD rats by high-glucose feeding (70% calories from glucose) for 6 weeks. The IR rats was then divided into IR group (n=10) and rosiglitazone (RSG) group (n=10). Rats in RSG group were treated with RSG 10 ?mol?kg -1?d -1 for 6 weeks by gavage. Ultrastructure of ? cells was observed with transmission electron microscope. Results Systolic blood pressure and serum levels of triglyceride, free fatty acids and insulin in RSG group were lower than those in IR group (all P
