Effect of lipid-induced insulin resistance on glucose metabolism in rats
- VernacularTitle:脂质诱导的胰岛素抵抗对大鼠糖代谢的影响
- Author:
Gangyi YANG
;
Zerong LIANG
;
Ling LI
- Publication Type:Journal Article
- Keywords:
Glucose metabolism;
Insulin resistance;
Lipids
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-mediated glucose metabolism of peripheral tissue and liver was assessed by euglycemic hyperinsulinemia clamp technique in lipid-infused rats. There was a significant increase in plasma free fatty acids and a significant reduction in glucose infusion rates in the lipid-infused group. The suppressive effect of insulin on hepatic glucose production (HGP) was significantly blunted and the rate of glucose disappearance showed a slight decrease in the lipid-infused rats, suggesting that lipid impaired the abilities of insulin to suppress lipolysis, HGP and insulin-mediated glucose utilization in peripheral tissues.
