Non-islet cell tumor-induced hypoglycemia due to overproduction of insulin-like growth factor-Ⅱ——two case reports and literature review
- VernacularTitle:胰岛素样生长因子Ⅱ过度分泌引起的非胰岛细胞肿瘤性低血糖——2例报告与文献复习
- Author:
Jieli LU
;
Yongju ZHAO
;
Jinfeng TANG
;
Jianming LIU
;
Weiqing WANG
;
Wei ZHANG
;
Yanyun GU
;
Bangyao LUO
;
Xiaoying LI
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor-Ⅱ;
Circulating GH-IGF axis;
Non-islet cell tumor hypoglycemia
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between abnormal circulating GH-insulin-like growth factor (IGF) axis and hypoglycaemia was explored in 2 cases of non-islet cell tumor associated hypoglycaemia (NICTH). Serum level of IGF-Ⅱ was increased, the levels of GH, IGF-Ⅰ, IGFBP-3 were decreased to some extent, and IGF-Ⅱ/IGF-Ⅰ (molar ratio) was significantly increased in these two cases. In one case, circulating GH-IGF axis returned to normal after complete removal of the tumor. In the diagnosis of NICTH, the abnormal circulating GH-IGF axis is quite valuable and IGF-Ⅱ/IGF-Ⅰ appears to be a more sensitive parameter.
