Relationship between soluble CTLA-4 and shift of serum Th_1/Th_2 cytokine balance in patients with Graves′ disease
- VernacularTitle:Graves病血清sCTLA-4与Th_1/Th_2细胞因子平衡偏离的关系
- Author:
Xiahong LIN
;
Xisheng LI
;
Ling LIN
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Th 1 cells;
Th 2 cells;
Cytotoxic T lymphocyte associated antigen-4
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) and imbalance of Th 1/Th 2 cytokines was investigated in patients with Graves′ disease. The results showed that sCTLA-4 was increased, IL-4 decreased. IFN-? did not significantly change, IFN-?/IL-4 was raised and there was a negative linear correlation between sCTLA-4 and IL-4, suggesting that imbalance of serum Th 1/Th 2 cytokines with a decline in Th 2 cytokine was associated with increased sCTLA-4.
