Puerarin reduces serum levels of advanced glycation end products and monocyte chemoattractant protein-1 in diabetic rats
- VernacularTitle:葛根素降低糖尿病大鼠血清糖基化终产物水平和单核细胞趋化蛋白1含量
- Author:
Jing LU
;
Naifeng LIU
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
Glycosylation end products, advanced;
Monocyte chemoattractant protein-1;
Puerarin;
Diabetes mellitus, experimental;
Rats, Sprague-Dawley
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of puerarin on advanced glycation end products (AGEs) and expression of monocyte chemoattractant protein-1 (MCP-1) in diabetic rats. Methods The rats were randomly divided into normal control rats (CON rats), diabetic rats (DM rats), diabetic rats treated with aminoguanidine (AG rats), and diabetic rats treated with puerarin (PU rats). The diabetic rat model was induced by streptozotocin. The serum levels of AGEs and MCP-1 were quantified by fluorescence spectroscopy and ELISA respectively. Tissue sections with PAS staining and electronic microscopy were used for observation of the pathologic changes in renal tissues. Immunohistochemistry was applied to detect the expression of MCP-1 protein in renal cortex. Results Serum levels of AGEs and MCP-1 in DM rats were higher than those in PU rats and AG rats (both P
