Protective effect of ischemic preconditioning on coronary microcirculation function by intracoronary Doppler guidewire assessment
- VernacularTitle:多普勒导丝评价缺血预处理保护冠状动脉微循环功能的实验研究
- Author:
Yu YANG
;
Yong XIA
;
Lei LI
- Publication Type:Journal Article
- Keywords:
Endosonography;
Ishchemic preconditioning;
Myocardial stunning;
Coronary circulation
- From:Chinese Journal of Ultrasonography
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ischemic preconditioning (IPC) on coronary microcirculation function in short-term hibernating myocardium(SHM) animal model.Methods Twelve little domestic Chinese pigs were established as the model of SHM by interventional method (closed-chest) and divided into 2 groups at random: the control group (CON group, n =6) and ischemic preconditioning group (IPC group, n =6).IPC was elicited by 2 cycle of 5 min of ischemia followed by 5 min of reperfusion before the establishment of model.Intracoronary Doppler guidewire was used to measure average peak velocity (APV),diastolic systolic velocity ratio(DSVR) and coronary flow reserve(CFR) of the distal to the stenosis at the baseline and 10 min,30 min,60 min,120 min after the establishment of model.Results APV,DSVR and CFR all decreased significantly in SHM model in both groups( P 0.05 ),at 60 min CFR of the CON group decreased significantly than before( 0.96 ? 0.27 vs 1.74 ? 0.49 , P 0.05 ).Conclusions The coronary microcirculation dysfunction happened at the time point of 60 min after coronary stenosis in SHM model,IPC can protect the coronary microcirculation function in SHM model.
