Study on changes and correlation of insulin-like growth factor-1 and bone mineral density in Graves disease
- VernacularTitle:Graves病患者胰岛素样生长因子-1水平和骨密度相关性研究
- Author:
Kejian XIE
;
Furong PAN
;
Yuxiang XIA
;
Yu GUAN
- Publication Type:Journal Article
- Keywords:
Graves disease;
Insulin-like growth factor-1;
Bone mineral density;
Thyroid hormone;
Radioimmunoprecipitation assay
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes and correlation of Insulin-line growth factor-1(IGF-1)and bone mineral density(BMD)in Graves disease(GD).Methods:The serum IGF-1 levels were determined by radioimmunoprecipitation assay(RIA) in 30 cases of females GD patients before and after successful therapy,the BMD were measured by dual-energy X-ray absorptiometry,the sex and ege were matched with the normal of the control group.Results:The levels of serum IGF-1(165 4?40 0) ?g/L markedly increase and the BMD(0 770?0 081)g/cm 2 markedly descend in GD group.There were significantly different from normal controls[IGF-1(92.5?25.1)?g/L、BMD(0.877?0.069)g/cm 2]( P0.05 ).Conclusion:IGF-1 probably play an important role in the pathogenesis and bone metabolism of GD.
