Protective effect of sivelestat sodium on ischemia reperfusion brain injury in rats
- VernacularTitle:西维来司钠对实验性大鼠脑缺血再灌注损伤的保护作用
- Author:
Jiadan YANG
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia reperfusion damage;
Sivelestat sodium;
Neuron;
Cell culture
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the protective effect of sivelestat sodium on cerebral ischemia reperfusion in rats and its mechanism.Methods:The neurons of neonate rat were cultured in vitro.The protective effects of sivelestat sodium on ischemia injury were observed by treating cells in glucose-free and oxygen-free medium.Results:Sivelestat sodium(10-8、10-7 and 10-6mol/L)increased the activity of neurons,reduced the leakage rate of LDH,increased the activity of SOD and reduced the content of MDA.Conclusion:sivelestat sodium protects the neurons against ischemia injury by suppressing the generation of lipid peroxide.
