The study of plasma homocysteine level, the methylenetetrahydrofolate reductase A1298C polymorphism, the methionine synthase A2756G polymorphisms and their association to coronary artery disease in the elderly
- VernacularTitle:老年人亚甲基四氢叶酸还原酶、蛋氨酸合成酶基因多态性及同型半胱氨酸水平与冠心病的关系
- Author:
Fusui JI
;
Hairong FAN
;
Fucheng SUN
;
Qing HE
;
Shu WANG
;
Feng XU
;
Yongjing XIA
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Cysteine;
Methylenetetrahydrofolate dehyclrogenase
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between the plasma homocysteine level and coronary artery disease(CAD), and the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism, the methionine synthase (MS) A2756G polymorphism and their associations to the plasma homocysteine level and CAD in the elderly . Methods One hundred and twenty-nine elderly patients with CAD documented by coronary angiogram and 48 elderly patients with normal coronary angiographic results were included in this study. Plasma homocysteine level were measured by fluorescence polarization immunoassay (FPIA) method and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyse the MTHFR A1298C and MS A2756G genotypes. Results The plasma homocysteine level was significantly higher in CAD group than that in the control group〔(16.2?8.6) ?mol/L vs (12.7?5.0) ?mol/L,P0.05);the prevalence of MTHFR 1298CC homozygous in the CAD patients was significantly less than that in the control group (3.1% vs 14.6%, P
