Detection of PMP, GPⅡb-Ⅲa, PAgT and their significances in cerebro-thrombotic diseases
- VernacularTitle:老年脑血栓形成患者血小板微颗粒、表面膜糖蛋白Ⅱb-Ⅲa、聚集率的检测
- Author:
Chuanxin WANG
;
Zhenduo LU
;
Xiaomei DENG
;
Enji HAN
;
Guangrun XU
- Publication Type:Journal Article
- Keywords:
Intracranial thrombosis;
Platelet glycoprotein GPⅡb-Ⅲa complax;
Platelet aggregation;
Flow cytometry
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function and clinical significance of platelet-derived microparticles (PMP), glycoprotein(GP)Ⅱb-Ⅲa, PagT and blood-lipid in whole blood of patients with cerebro-thrombotic diseases before and after treatment. Methods The quantity of PMPs, activation ratio of GPⅡb-Ⅲa and PAgT were measured before and after treatment of cerebro-thrombotic patients by using flow cytometry and platelet adhesion instrument. Blood-lipid concentration was measured by automatic-biochemical analyzer. Results PMP, GPⅡb-Ⅲa , PAgT, TC, TG, and LDL were (223?54)/10 4 Plt, (77.98?14.22)%, (69.78?16.93) %, (5.12?0.85) mmol/L, (1.78?0.28) mmol/L, and (3.49?0.66) mmol/L respectively before treatment; and were (136?18)10 4Plt, (40.71?11.64) %, (58.12?12.51)%, (4.84?0.73) mmol/L, (1.43?0.33) mmol/L, and (3.03?0.62) mmol/L,respectively in the treatment group. These parameters were significantly decreased than that before treatment (P
