Influence of micrometastasis in pathologically negative lymph node on staging and prognosis of oral squamous cell carcinoma
- VernacularTitle:口腔鳞癌淋巴结微转移灶检测对分期和预后的影响
- Author:
Hongwei ZHAO
;
Longjiang LI
;
Wenyang XIE
- Publication Type:Journal Article
- Keywords:
Mouth;
Squamous cell carcinoma;
Lymphatic micrometastasis;
Prognosis;
Neoplasm staging
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the influence of micrometastasis in lymph node on the prognosis of oral squamous cell carcinoma(OSCC).Methods: In 36 patients micrometastasis in pathologically negative lymph nodes were tested by immunohistochemical cytokeratin(CK) examination and the relationship between CK+ and survival time of the patients was analyzed. Results: The survival time(month) of CK+ and CK- patients was 36.76?6.91 and 47.47?11.35 respectively(P=0.002).Multivariate analysis of Logistic regression model showed that micrometastasis in lymph node (P=0.044)and histologic grade (P=0.040) were regarded as independently prognostic factors while clinical stage (P=0.236)did not. Conclusion: The detection of micrometastasis in the lymph nodes may serve as a supplement to the present staging system of OSCC. The prognosis of patients with micrometastasis is poorer than those without micrometastasis.
