THE CHANGE OF NA~(+)-K~(+)-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS
- VernacularTitle:糖尿病红细胞膜Na~+—K~+—ATP酶活性的改变及其影响因素
- Author:
Huacong DENG
- Publication Type:Journal Article
- Keywords:
NIDDM;
Na+-K+-ATPase activity;
Red cell deformability
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Na+-K+-ATPase activity of the erythrocyte plasma membrane in noninsulin-de- pendent diabetes mellitus (NIDDM) was studied together with the red cell deform-ability (RCD) and other influencing factors. Comparing with the normal controls, Na+-K+-ATPase activity, Mg++-ATPase activity, and RCD in diabetics were significantly decreased, and the erythrocyte membrane cholesterol and lipid peroxide, fasting blood glucose, and glycosylated hemoglobin were significantly increased. The change of Na+-K+-ATPase activity was positively correlated with RCD, and inversely correlated with fasting blood glucose, erythrocyte membrane cholesterol, and lipid peroxide. The results suggested that the change of Na+-K+-ATPase activity in erythrocyte may contribute to the alterations of RCD in diabetics
