Application of prostaglandin E1 improves graft viability in the immediate period after liver transplantation
- VernacularTitle:前列地尔促进移植肝功能早期恢复的临床研究
- Author:
Yi LU
;
Xuewen JI
;
Hui LI
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Reperfusion injury;
Alprostadil;
Recovery of function
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cytoprotective effect of prostaglandin E1(PGE1)in the imme- diate period after orthotopic liver transplantation (OLT).Methods Ten patients undergoing OLT were divided into 2 groups: group P (n=6) was administered with PGE1 and group C (n=4) served as control group. Serum ALT, AST, TBIL, DBIL, bile output and the period of intensive care unit (ICU) in both groups were observed in the first 3 weeks after OLT. Results Postoperative increases in serum ALT, AST, TBIL and DBIL levels were significantly suppressed by PGE1. In addition, PGE1 contributed distinctly to an increase of bile output (P
