The association of HLA-DRB1 alleles with macrovascular complication of type 2 diabetics in Han race of Chinese north area
- VernacularTitle:HLA-DRB1等位基因与中国北方地区汉族人2型糖尿病大血管病变的相关性研究
- Author:
Weihua WU
;
Guoliang LIU
;
Fenglin CAO
;
Jinchao ZHANG
- Publication Type:Journal Article
- Keywords:
HLA-DRB1 alleles;
China;
T2DM;
Macrovascular complication
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between HLA-DRB1 gene polymorphisms and macrovascular complication of type 2 diabetics. Methods:HLA-DRB1 alleles in 88 cases of type 2 diabetics, including 52 ones without complication and 36 ones with macrovascular complication, were examined by PCR-SSP. Results:There were at least 11 HLA-DRB1 alleles in type 2 diabetics. The HLA-DRB1 *03 and HLA-DRB1 *09012 gene frequencies of type 2 diabetics with macrovascular complication were significant higher than those without complication.Conclusion:HLA-DRB1 *03 and HLA-DRB1 *09012 alleles or their linkage disequilibrium genes may enhance the risk of the development of type 2 diabetes macrovascular complication.
