The study on the experiment of hepatocarcinoma with homogenous spleenocytes activated by IL-2 and Tremella Polysaccharide
- VernacularTitle:IL-2联合银耳多糖激活的同种脾细胞对肝癌实验性治疗的研究
- Author:
Zhiheng DONG
;
Chunli WEI
;
Meng QU
;
Zhe FAN
- Publication Type:Journal Article
- Keywords:
Tremella Polysaccharide;
IL-2;
Hepatocarcinoma;
Immunotherapy spleenocyte;
Spleenocytes
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the cytotoxicity to tumor cells P815,H22 and B16 in vitro and the treatment effect of mice spleenocytes activated by lymphokine IL-2 and Tremella Polysaccharide,and their effects on main viscerals.Methods:The cytotoxicity of spleenocytes activated by lymphokine IL-2 or IL-2 and Tremella Polysaccharide to P815,H22 and B16 was detected by ?-scintillation counter after 2 hours.Subcutaneous injection of the above-mentioned spleenocytes to the local area of jepatocarcinoma of mice,one injection every two days,5 times totally.To examine tumor weight,size,histological changes and morphological changes in main viscerals.Results:The significantly cytotoxicity to tumor cells of spleenocytes activated by IL-2 and Tremella Polysaccharide was observed.To B16,the cytotoxicity of activated spleenocytes was the strongest.To H22,the cytotoxicity of activated spleenocytes was stronger and to P815,the cytotoxicity was the weakest,the cytotoxicity of TP-LAK cells was significantly stronger than that of LAK cells( P
