The effects of HMGCoA agents and ACE inhibitor on the serum inflammatory markers in patients with acute coronary syndrome
- VernacularTitle:他汀类调脂药和ACEI对急性冠脉综合征患者血清中炎性指标的影响
- Author:
Shaomin CHE
;
Yanni WANG
;
Aiqun MA
;
Lu GAO
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
inflammation;
ACE inhibitor;
follow-up
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of HMGCoA agents and ACE inhibitor on serum inflammatory markers in patients with acute coronary syndrome (ACS). Methods The 60 patients with ACS were randomly divided into two groups, one treated with lipid lowered by HMGCoA agents and the other treated with HMGCoA agents added with ACE inhibitor. After 4 months, serum levels of some inflammatory markers were measured by means of ELISA. Results Serum levels of certain inflammatory markers were significantly higher in the ACS group than in the control group and became significantly lower 4 months later in the follow-up group. There were no differences in all the inflammatory markers between the two groups receiving different therapies 4 months later. Conclusion Serum levels of some inflammatory markers may have certain diagnostic value for ACS and may reflect the stability of the disease. HMGCoA agents seem to have no effect on inflammatory responses in a short period.
