Serum levels of nitric oxide in type 2 diabetes mellitus and its relationship with diabetic peripheral neuropathy
- VernacularTitle:一氧化氮与2型糖尿病及其神经病变的关系
- Author:
Wanhong LU
;
Xiaoli YAO
- Publication Type:Journal Article
- Keywords:
nitric oxide;
nitric oxide synthase;
diabetes mellitus;
diabetic peripheral neurology
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of serum nitric oxide level in patients with type 2 diabetes (2-DM) and in patients with diabetic peripheral neurology (DPN). Methods Nitrose reductase method was used to examine the serum concentration of NO in type 2 diabetics (n=74) and those accompanied with DPN (n=22) and without DPN (n=21). Results ① The serum NO level in the early stage of metabolic disorder of 2-DM patients was higher than that in the control group; it showed a declining trend in the process of DM and was significantly lower in the middle and late stages of DM. ② The 2-DM patients with DPN had significantly lower serum NO level than in those without DPN, but no difference was observed in serum NO level between the diabetics with mild DPN and severe DPN. Conclusion ① Serum NO level in 2-DM patients has a descending changes in the progression of the disease. ② Serum NO level is closely correlated with the occurrence of DPN, but has no obvious association with its progression.
