Changes of aquaporin-4 expressions in experimental rats after intracerebral hemorrhage
- VernacularTitle:实验性脑出血后水通道蛋白-4的表达变化
- Author:
Yanhua LI
;
Shanquan SUN
- Publication Type:Journal Article
- Keywords:
Brain edema;
Cerebral hemorrhage;
Aquaporins
- From:
Chinese Journal of Neurology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of aquaporin-4 (AQP4) and cerebral edema formation during the pathologic course of hemorrhagic cerebral edema. Methods The intracerebral hemorrhage (ICH) was established by infusing collagenase into rat caudate nucleus. In situ hybridization and immunohistochemistry were respectively used to evaluate AQP4 mRNA and protein expression, and electronic microscopy and microangium perfusion were respectively used to observe the changes of the ultrastructural and local capillaries in perihematomal brain edema. Results As compared with the control group, there appeared a significant increase in AQP4 mRNA and protein expression on the edematous tissue at 6 hours in rats following ICH. AQP4 mRNA expression (optical density, A) was increased from 0.29 to 0.57 (P0.82, P s
