The relationship between TGF-?_1 mRNA and acute rejection of small intestinal allografts in rats
- VernacularTitle:TGF-?_1 mRNA与大鼠小肠同种异体移植急性排斥反应的关系
- Author:
Feng ZHAO
;
Lihong LU
;
Jun SHAO
;
Jinlin YIN
- Publication Type:Journal Article
- Keywords:
Transforming growth factor-beta?Intestinal transplantation?Acute rejection?Rats
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between TGF-? 1mRNA and acute rejection of small intestinal allografts in rats.Methods:Rats were divided into two groups.Group Ⅰ:Wistar→SD Small intestinal transplantation,Group Ⅱ:Wistar→SD Small intestinal transplantation+CsA.The pathologic changes of allografts at 3 rdday,5 thday,7 thday after operation investigated and the transcription of IL-2,IFN- ?,and TGF-? 1mRNA was detected by semi-quantity RT-PCR.Results:Pathologic change:There was acute rejection at 3 rdday,and became severe at 7 thday in group Ⅰ,and there was only slight rejection at 7 thday in groupⅡ.TIFN-?、IL-2mRNA obviously increased after operation in groupⅠ.But they increased only a little in group Ⅱ.It had statistical significance between the two groups(P
