Study of CK19 mRNA in blood of patients with colorectal cancer
- VernacularTitle:结直肠癌患者外周血CK19 mRNA检测的意义
- Author:
Xiang DU
;
Menghong SUN
;
Huiqun XIA
- Publication Type:Journal Article
- Keywords:
colorectal neoplasm;
peripheral blood;
CK19 mRNA
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To detect the mRNA expression of epithelial skeleton protein CK19 in the peripheral blood of patients with colorectal cancer; to study its relationship to other clinicopathological parameters; and to discuss if the detection can help post-operative adjuvant therapy. Methods: A total of 39 blood samples from colorectal cancer patients were included in the study. Specific RT-PCR primers were used to avoid the amplification of pseudogenes. Results: Of 39 patients 31 showed CK19 mRNA expression (79.5%) . The patients in Dukes stage C and D showed higher frequency of CK19 mRNA expression than that in Dukes A and B (P
