Expression of Survivin gene in human non-small-cell lung cancer: association with Caspase-3 and Bcl-2
- VernacularTitle:凋亡抑制基因Survivin在非小细胞肺癌中的表达及其与Caspase-3、Bcl-2蛋白表达的关系
- Author:
Feng YAO
;
Lin TAO
;
Qian CHEN
- Publication Type:Journal Article
- Keywords:
lung neoplasm;
in situ hybridization;
immunohistochemistry;
Survivin gene;
apoptosis
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To investigate the expression of Survivin gene and its relationship with expression of Caspase-3, B-cell lymphoma-2( Bcl-2) in human non-small-cell lung carcinoma( NSCLC) . Methods: Expression of the Survivin mRNA was evaluated by in situ hybridization (ISH) in 13 normal bronchial epithelium, 11 dysplasia, 54 NSCLC and 12 lymph node metastasis. Immunohistochemical assay was used to detect the expression of Caspase-3 and Bcl-2 proteins. Results: Expression of Survivin was detected in a significantly greater proportion in NSCLC (74. 07%) and lymph node metastasis (91. 67%) than normal bronchial epithelium (7. 69%) and dysplasia ( 27. 27%) (P
