Relationship between hypoxia and estrogen receptor alpha in human breast cancer
- VernacularTitle:乳腺癌组织缺氧与雌激素受体-?的关系
- Author:
Guangyu LIU
;
Kunwei SHEN
;
Zhimin SHAO
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
estrogen receptor;
hypoxia
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: Hypoxia is common in breast cancer and may influence gene expression to promote malignancy. Estrogen receptor (ER) -? status is an important predictor for both prognosis and clinical response to endocrine therapy. The aim of our current study is to demonstrate the relationship between hypoxia and ER-? in breast cancer tissue. Methods: We have examined ER-a expression by immunohistochemistry in parallel with indicators of hypoxia in 51 ER-a ligand binding assay positive breast tumors for in vivo evidence of this phenomenon. Results: Overall, 49 tumors were ER-a positive by immunohistochemistry. Regional loss of ER-a expression was consistently present in peri-necrotic as compared to distant regions in both in situ (n =29, P
