Expression of matrix metalloproteinase-2 in lymph node-negative breast carcinoma and its clinical value
- VernacularTitle:基质金属蛋白酶-2在淋巴结阴性乳腺癌中的表达及临床意义
- Author:
Daocheng CAO
;
Hecheng LI
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
matrix metalloproteinase-2;
lymph node-negative;
prognostic factor
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To study the expression of MMP-2 in lymph node-negative breast carcinoma and its relation to other factors and its clinical value. Methods: Paraffin-embedded specimens from 270 patients with lymph node-negative breast carcinoma were studied. MMP-2 were investigated by immunohistochemical staining. Results: Positive staining for MMP-2 were observed in some breast carcinoma cells. Positive staining of MMP-2 was significantly related to higher tumor grade and larger tumor size but not ER, PR and other factors. It was also significantly associated with patients relapse free survival but not overall survival. Conclusions: MMP-2 is an unfavorable prognostic factor in lymph node-negative breast carcinoma patients and it is an important prognostic factor.
