Expression of KAI1 protein and its clinicopathological significance in breast cancer
- VernacularTitle:乳腺癌中KAI1蛋白表达与临床病理特征的相关性
- Author:
Meifu CAN
;
Ying WU
;
Hansong CHEN
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
metastasis suppressor gene;
KAI1;
immunohitochemistry
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To investigate the expression of KAI1 protein and its clinicopathological significance in breast cancer. Methods: Immunohistochemical staining ( S-P method) was used to detect the expression of KAI1 protein in specimens from 107 breast cancer and 30 adjacent normal breast tissues. Results: KAI1 protein positive rate in breast cancer tissues is significantly lower than that of adjacent nomal breast( P 0. 05). Conclusions: These data suggest that in advanced breast cancer, KAI1 is down-regulated and decrease in KAI1 ecpression plays an important role in the malignant progression of breast cancer. Therefore, detection of KAI1 protein might be a potentially valuable indicator for staging human breast cancer and predicting prognosis.
