Advances in research on ATM as a target for novel radiosensitizers
- VernacularTitle:放射治疗增敏的新靶点ATM的研究进展
- Author:
Jinsong YANG
;
Xueguan LU
;
Yan FENG
- Publication Type:Journal Article
- Keywords:
radiotherapy;
radiosensitizer;
ATM gene;
A-T syndrome
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Patients with ataxia-telangiectasia ( A-T) syndrome were charachaterized by profound hypersensitivity to ionizing radiation in clinic. Many studies have shown that this hypersensitivity possibly attributed to ATM gene whose critical compartment was ATM kinase. So inhibitors of the ATM kinase such as caffeine, pentoxifylline, methyl xanthines and 7-hydroxystaurosporine (UCN-01) were developed and have achieved a few encouraging results in basic and clinical stuides.
