Imbalance of Th_1/Th_2 cells in thyroid tissues of patients with autoimmune thyroid diseases
- VernacularTitle:自身免疫性甲状腺疾病患者甲状腺内Th_1/Th_2细胞失衡研究
- Author:
Wei CUI
;
Bingyin SHI
- Publication Type:Journal Article
- Keywords:
Thyroid diseases, autoimmune;
Graves′ disease;
Thyroiditis, autoimmune;
Th 1/Th2 cells
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the imbalance of Th 1/Th 2 cells in the pathogenesis of autoimmune thyroid diseases (AITD). Methods Thirteen patients with Graves′ disease (GD), 12 patients with Hashimoto′s thyroiditis (HT) were recruited for the study, and 8 patients with non-toxic nodular goiter served as controls. The expressions of interferon-? (IFN-?) and interleukin-4 (IL-4) of intrathyroidal mononuclear cells (ITMC), representative cytokines of Th 1 and Th 2 cells respectively, were assayed by immunohistochemical technique. Thyroid stimulating antibody (TSAb), thyroglobulin antibody (TGAb) and thyroid microsome antibody (TMAb) in peripheral blood were detected by routine methods, and their correlations with the IFN-? and IL-4 were analyzed. Results (1) Compared with the controls, the IL-4 and IFN-? expressions of ITMC in GD and HT patients were remarkably increased (both P
