Association of polymorphisms of estrogen receptor-? and vitamin D receptor genes with peak bone mass in Shanghai women
- VernacularTitle:雌激素受体?和维生素D受体基因多态性与上海市妇女峰值骨量的关系
- Author:
Jinwei HE
;
Qiren HUANG
;
Zhenlin ZHANG
;
Yuejuan QIN
;
Jinhui LU
;
Miao LI
;
Qi ZHOU
;
Yunqiu HU
;
Yujuan LIU
;
Hao ZHANG
- Publication Type:Journal Article
- Keywords:
Bone density;
Receptors, estrogen;
Receptors, calcitriol (Receptors, vitamin D);
Genes;
Polymorphism (Genetics)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of estrogen receptor-? (ER-?) and vitamin D receptor (VDR) gene polymorphisms with peak bone mass in Shanghai women. Methods The ER-? PvuⅡ and XbaⅠ genotypes and VDR ApaⅠ genotypes were determined by PCR-RFLP in 515 unrelated healthy women aged 19-40 years of Han nationality in Shanghai. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Results Frequencies of ER-? PvuⅡ genotype PP, Pp and pp were 13.2%, 49.3% and 37.5% respectively. Frequencies of ER-? XbaⅠ genotype XX, Xx and xx were 4.7%, 40.4% and 54.9% respectively. Frequencies of VDR ApaⅠ genotype AA, Aa and aa were 5.8%, 41.9% and 52.3% respectively. Hardy-Weinberg equilibrium was evident for both ER-? and VDR gene polymorphisms. No association was found between ER-? PvuⅡ and XbaⅠ genotypes and BMD of various sites in women. Only a significant association was found between VDR ApaⅠ genotype and BMD at L 1-4(P
