Effect of estrogen on experimental autoimmune thyroiditis in Wistar rats
- VernacularTitle:雌激素对大鼠实验性自身免疫性甲状腺炎的影响
- Author:
Xiaoqin GUO
;
Enjiang TIAN
;
Jiali ZHANG
;
Shujun ZHAO
;
Jinlong WANG
- Publication Type:Journal Article
- Keywords:
Thyroiditis, autoimmune;
Estradiol;
Interferon-? (Interferon type Ⅱ)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of estradiol-17? (E 2-17?) on the induction of experimental autoimmune thyroiditis (EAT). Methods Ten-week old female Wistar rats were ovariectomized (OVX). EAT of Wistar rats was induced by immunization with thyroglobulin (Tg) from SD rats in the presence of complete Freund′s adjuvant. Thyroiditis was pathologically evaluated by HE staining. E 2-17? and PRL levels were measured by RIA, anti-Tg antibody (TgAb) was detected by ELISA, and interferon (IFN)-?, interleukin (IL)-10 mRNA in thyroid were assayed by RT-PCR. Results The serum level of E 2-17? (17.60?1.02)pmol/L and PRL (2.45?0.15)?g/L were much lower in OVX rats than intact rats 〔(58.56?6.99)pmol/L and (3.22?0.17)?g/L, respectively〕 (both P
