Focal region of high intensity focused ultrasound combined with ultrasound contrast agent on rabbit liver
- VernacularTitle:高强度聚焦超声联用超声造影剂对治疗兔肝焦域效应的影响
- Author:
Weihong SHA
;
Yuyuan LI
;
Yuqiang NIE
- Publication Type:Journal Article
- Keywords:
High intensity focused ultrasound;
Contrast amedia;
Rabbit;
Liver
- From:
Chinese Journal of Ultrasonography
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of high intensity focused ultrasound (HIFU) combined with ultrasound contrast agent on rabbit liver, and to investigate the possibility of ultrasound contrast agents enhancing the effect of HIFU on rabbit liver. Methods Thirty-two rabbits were averagely divided into two groups according to their body mass. Rabbits in group Ⅰ were irradiated by HIFU alone on the liver, and those in group Ⅱ were treated by irradiation of HIFU after intravenous injection of a ultrasound contrast agent. The used treatment time, frequency, power and the distance from focus to the skin surface were identical in the two groups. The changes of ultrasound image were recorded at the 20 s, 2 min and 5 min after treatment. Four rabbits in each group were slaughtered for morphological and pathological examination immediately and on the 2nd, 3rd and 7th day after the treatments, respectively. Results The ultrasonic gray scale differenced in the HIFU alone group were ( 20.12? 12.4)s (20 s), ( 16.8? 9.3)min (2 min) and ( 15.1? 11.9)min (5 min). Compared with those in the enhanced HIFU group were ( 63.9? 29.4)s, ( 60.0? 25.9)min, ( 59.3? 28.7)min, respectively(P
