Study on gap junctional mediated intercellular communication in detrusor instability
- VernacularTitle:逼尿肌不稳定缝隙连接介导细胞间通讯的研究
- Author:
Fenghai ZHOU
;
Bo SONG
;
Xiyu JIN
- Publication Type:Journal Article
- Keywords:
Detrusor instability;
Fluorescence redistribution after photobleaching
- From:
Chinese Journal of Urology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the functional changes of gap junctional mediated intercellular communication in detrusor instability so as to demonstrate the feasibility of blocking excitatory communication as the target of therapy for DI. Methods The function of GJIC in the cultured bladder detrusor cells were detected by FRAP. Results At the fourth minutes after bleaching,the mean fluorescences recovery rates of the DI groups bladder detrusor cells was (35.791?0.836)%,the control groups (8.645?0.673)%.The mean fluorescences recovery rates of the DI groups were significant higher than those in control groups (P
