Effects of Bile from Patients with Cholecystolithiasis on the Growth of Human Gallbladder Carcinoma Cells
- VernacularTitle:胆囊结石患者胆汁对人胆囊癌细胞增殖的影响
- Author:
Gaosong WU
;
Shengquan ZOU
- Publication Type:Journal Article
- Keywords:
Cholecystolithiasis Bile Gallbladder carcinoma Cell proliferation
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of bile from patients with cholecystolithiasis on the growth of human gallbladder carcinoma cells GBC-SD and the potential correlation between cholecystolithiasis and gallbladder carcinoma. Methods Cholecystolithiasis bile (CB) and normal bile (NB) specimens were used for this study. The proliferative effects of bile were measured by methabenzthiazuron (MTT) assay and cell cycle and apoptosis were analyzed by flow cytometry. Results CB can significantly promote the proliferation of GBC-SD cells, GBC-SD proliferative index increased significantly after treated with 1% CB for 48 h (P
