Application of acoustic densitometry technique on regression of rabbit atherosclerosis
- VernacularTitle:声学密度定量技术在兔动脉粥样硬化消退治疗中的应用
- Author:
Mei ZHANG
;
Yun ZHANG
;
Yuanyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Atherosclerosis;
Rabbits
- From:Chinese Journal of Ultrasonography
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of acoustic densitometry(AD) on evaluating effects of simvastatin, probucol, captopril and Chinese medicine on the atherosclerosis (AS) characterization of rabbit. Methods Sixty male New Zealand rabbits were divided randomly into five groups:normal group, regression control group(RC), simvastatin group, probucol group, captopril and Chinese medicine group. The intima-media thickness (IMT), lumen acoustic densitometry (AII-L), intima-media acoustic densitometry (AII-I), adventitia acoustic densitometry (AII-A) and corrected acoustic densitometry (AIIc) of abdominal aorta were measured with high frequency ultrasound at the beginning, the 12th and 24th week of the experiment. Abdominal aorta was also examined through pathology at 24th week of the experiment. Results Analysis of abdominal aortas from 8 rabbits in vitro showed the different effects of the different frequencies of transducer on the AII value of lumen, intima-media and the adventitia. AIIc was calculated to evaluate acoustic density of intima-media to avoid the influence of individual divergence.AIIc in 4 drug-therapy groups were significantly higher than AS model group (P
