A study on apoptosis of lymphocytes and expression of apoptotic protein in patiens with idiopathic thrombocytopenic purpura
- VernacularTitle:特发性血小板减少性紫癜淋巴细胞凋亡及凋亡蛋白表达的研究
- Author:
Fang LIU
;
Hong XIAO
;
Qiong MENG
;
Kangrong CAI
- Publication Type:Journal Article
- Keywords:
Idiopathic thrombocytopenic purpura;
Apoptosis;
Fas/FasL
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relations between the changes of apoptotic lymphocytes and expression of apoptotic protein and idiopathic thrombocytopenic purpura(ITP).Methods:Flow cytometry was used to detect the percentages of the apoptotic lymphocytes and the expression of Fas,FasL on peripheral lymphocytes,and the serum levels of sFas、sFasL were also determined by a sandwich enzyme-linked immunosorbent assay(ELISA),in 25 patients with ITP.Results:The percentages of the apoptotic lymphocytes(3.35?1.43) and the expression of Fas(32.17?6.54) and FasL(41.14?6.76)were all increased significantly in treated patients whose platelets recovered to normal( P
