The influence of the peripheral hematopoietic stem cell mobilization on circulating endothelial cells
- VernacularTitle:外周血造血干细胞动员对循环血管内皮细胞的影响
- Author:
Xiubao REN
;
Hui LI
;
Hong LIU
;
Peng ZHANG
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
Circulating endothelial cells (CECs);
Circulating endothelial precursors (CEPs);
Hematopoietic stem cell mobilization;
Tumor
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Analyze the influence of hematopoietic stem cell mobilization on circulating endothelial cells (CECs) and circulating endothelial precursors (CEPs).Methods:CECs and CEPs were enumerated in 68 tumor patients and 15 healthy controls by 3-color flow cytometry. 11 cases underwent PBSC (peripheral blood stem cell) mobilization by combination chemotherapy and G-CSF (granulocyte colony-stimulating factor).Results:CECs and CEPs in tumor patients were 0.378%?0.103% and 0.059%?0.013% respectively,which were higher than that of normal controls.CECs/CEPs in peripheral blood (PB) were increased after G-CSF mobilization.Conclusion:Hematopoietic and endothelial progenitors can be mobilized into the PB by treatment with growth factor G-CSF.
