A Study on the Effect of TACE on the Apoptosis Proteins fas, bax and bcl-xl in HCC
- VernacularTitle:经导管肝动脉栓塞化疗术(TACE)对肝癌细胞凋亡相关蛋白fas,bax和bcl-xl表达影响的相关研究
- Author:
Houfa NING
;
Bin WANG
;
Guiwen CAO
;
Yequan SUN
;
Dexin YU
- Publication Type:Journal Article
- Keywords:
carcinoma, hepatocellular;
chemoembolization, therapeutic;
apoptosis, genes
- From:
Journal of Practical Radiology
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of transcatheter arterial chemoembolization ( TACE ) on the apoptosis proteins fas,bax,and bcl-xl in hepatocellular carcinoma ( HCC ) . Methods Sixty-three cases with HCC proved by histopathologically were studied, which included 42 cases treated with surgical resection alone,and 21 cases underwent TACE . The expressions of fas,bax,bcl-2 and bcl-xl were detected with immunohistochemical SP method .Results The positive rate of fas was 47.62% ( 10/21 ) in HCCs treated with TACE,and 21.43%(9/42) in those treated with surgical resection alone, there was significantly difference between the two groups(?0.05). Conclusion TACE can increase the expression of fas and decrease the expression of bcl-xl, it can increase the rate of apoptosis of HCC, make HCC lesion contract. The effect of TACE to bax need more research.
