Effect of implantation of the bone marrow cells into infarct myocardium on the secretion of cytokines
- VernacularTitle:骨髓细胞移植入心肌梗死区对细胞因子分泌的影响
- Author:
Feng LIN
;
Chongxian LIAO
;
Yunbin YE
- Publication Type:Journal Article
- Keywords:
Bone marrow cell;
Cell transplantation;
Myo cardial infarction;
Stem cell factor
- From:
Chinese Journal of Organ Transplantation
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of implantation of the bone marrow cells into infarction myo cardium on the secretion of basic fibroblast growth factor (bFGF), insulin-like growth factor 1 (IGF-1), transforming growth factor-?1 (TGF-?1 ), interleu kin-1 (IL-1), and interleukin-8 (IL-8).MethodsBone marrow cells were implanted into the region of acute myocardial infarct via topical injection. Specimens were harvested at first, 2nd, 4th, 8th week after implantation for the expression of cytokines and vascular density examination by immunohistochemical analysis and the levels of cytokines by radioimmunoassay. ResultsAt first, 2nd, 4th, 8th week after transplantation, the vascular density in the bone marrow cell implant group was significantly higher than that in the control group (P
