Clinical Characteristics and Treatment Results of Pediatric Osteosarcoma: The Role of High Dose Chemotherapy with Autologous Stem Cell Transplantation.
- Author:
Ji Won LEE
1
;
Hyery KIM
;
Hyoung Jin KANG
;
Han Soo KIM
;
Sung Hye PARK
;
In One KIM
;
Hyo Seop AHN
;
Hee Young SHIN
Author Information
1. Division of Hematology/Oncology, Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. hyshin@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Osteosarcoma;
Autologous stem cell transplantation;
High dose chemotherapy;
Pediatrics
- MeSH:
Disease Progression;
Disease-Free Survival;
Humans;
Necrosis;
Neoplasm Metastasis;
Osteosarcoma;
Pediatrics;
Prognosis;
Recurrence;
Retrospective Studies;
Stem Cell Transplantation;
Stem Cells
- From:Cancer Research and Treatment
2008;40(4):172-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: In this study, we investigated the clinical characteristics and treatment results of osteosarcoma during the past 7 years, and evaluated the role of high dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT). MATERIALS AND METHODS: We retrospectively analyzed the clinical data of patients who were diagnosed as osteosarcoma at our center from January, 2000 to December, 2007. RESULTS: The 5-year overall survival and event-free survival of the patients were 72.6% and 55.9%, respectively. Seventeen (41.5%) patients showed disease progression during treatment or relapse after the end of treatment. The patients who had metastasis at diagnosis or who had a lower grade of necrosis after neoadjuvant chemotherapy showed decreased overall and event-free survival. Four patients received ASCT after HDCT, and 3 of them are alive without disease. CONCLUSIONS: The patients who relapsed or had refractory osteosarcoma or who had metastasis at diagnosis or a lower grade of necrosis after neoadjuvant chemotherapy showed poor prognosis. HDCT with ASCT could be an alternative treatment option for these patients.
